Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate

Bolt CC, Negi S, Guimarães-Camboa N, Zhang H, Troy JM, Lu X, et al. (2016) Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS ONE 11(4): e0154413. doi:10.1371/journal.pone.0154413 @PLOSone

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Study: Different species share a “genetic toolkit” for behavioral traits

CHAMPAIGN, Ill. — The house mouse, stickleback fish and honey bee appear to have little in common, but at the genetic level these creatures respond in strikingly similar ways to danger, researchers report. When any of these animals confronts an intruder, the researchers found, many of the same genes and brain gene networks gear up or down in response.

This discovery, reported in the Proceedings of the National Academy of Sciences, suggests that distantly related organisms share some key genetic mechanisms that help them respond to threats, said University of Illinois cell and developmental biology professor Lisa Stubbs, who led the research with animal biology professor Alison Bell and entomology professor and Institute for Genomic Biology director Gene Robinson. Bell and Stubbs also are IGB faculty.

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A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues

Bolt CC, Elso CM, Lu X, Pan F, Kispert A, Stubbs L. A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues. Dev Biol. 2014 May 20. pii: S0012-1606(14)00265-6. doi: 10.1016/j.ydbio.2014.05.010. [Epub ahead of print] @PubMed Continue Reading →