The vertebrate T-box transcription factor gene Tbx18 performs a vital role in development of multiple organ systems. Tbx18 insufficiency manifests as recessive phenotypes in the upper urinary system, cardiac venous pole, inner ear, and axial skeleton; homozygous null mutant animals die perinatally.
Bolt CC, Elso CM, Lu X, Pan F, Kispert A, Stubbs L. A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues. Dev Biol. 2014 May 20. pii: S0012-1606(14)00265-6. doi: 10.1016/j.ydbio.2014.05.010. [Epub ahead of print] @PubMed Continue Reading →
Nowick K and Stubbs L. Lineage-specific transcription factors and the evolution of gene regulatory networks. Briefings in Functional Genomics and Proteomics 9:65-78, 2010. @PubMed. Continue Reading →