Developmental Regulation

The vertebrate T-box transcription factor gene Tbx18 performs a vital role in development of multiple organ systems. Tbx18 insufficiency manifests as recessive phenotypes in the upper urinary system, cardiac venous pole, inner ear, and axial skeleton; homozygous null mutant animals die perinatally.

C. Chase Bolt, Ph.D.

C. Chase Bolt, Ph.D.

C. Chase Bolt, Ph.D.

Current Position:

Post-doctoral researcher. Laboratory of Denis Duboule.
École Polytechnique Fédérale de Lausanne.

Lausanne, Switzerland.

Current Contact Information


Doctorate of Philosophy, Cell and Developmental Biology
– University of Illinois 2008-2014
Bachelor of Science, Molecular and Cell Biology
– Bradley University 2005-2008


Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. C. Chase Bolt, Soumya Negi, Guimarães-Camboa N, Zhang H, Troy JM, Lu X, et al PLoS ONE. 2016;11: e0154413–20. PMID 27120339

A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues.
C. Chase Bolt, Colleen M Elso, Xiaochen Lu, Fuming Pan, Andreas Kispert, and Lisa Stubbs.
Developmental Biology, 2014 pp. 1-11.

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