Dr. Lisa J Stubbs

PROFESSOR OF CELL AND DEVELOPMENTAL BIOLOGY

PROFESSOR OF CELL AND DEVELOPMENTAL BIOLOGY

Education
  • B.S. University of Puget Sound (Biology)
  • Ph.D. University of California, San Diego (Biology)
  • Postdoc. California Institute of Technology, Pasadena CA; European Molecular Biology Laboratory, Heidelberg, Germany

Research Interests
Evolution of gene regulatory networks; Long-range regulatory mechanisms; Mouse models of human disease, Bioinformatics, Chromatin Structure, Development, Genomics, Molecular Evolution, Regulation of Gene Expression

Our research combines mouse genetics, bioinformatics and genomic methods to explore cis- and trans-acting components of mammalian gene regulatory machinery. We are particularly interested in those components of the regulatory machinery that have changed over evolutionary time. Working against a background of deep conservation, these changing components hold potential to explain biological differences between species, but also between different individuals in the same populations.

I have long been interested in the mechanisms of genome evolution, and especially in the functional impact of genome rearrangements, gene duplication and gene loss on species-specific aspects of gene regulation during development and differentiation. My group’s current work is focused in two areas: (1) Determining the functions of genes encoding conserved and species-variant Kruppel-type zinc finger (KZNF) transcription factors; and (2) Investigating mechanisms of long-distance gene regulation, and understanding how these mechanisms can be perturbed to yield developmental variation, using a unique collection of translocation mutant mice combined with transgenic mouse technology.

To find out more about areas of ongoing research in my lab, browse the science section or download our most recent publications.

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Contact Information:
Institute for Genomic Biology Rm 2402/2500
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Office: (217) 244-4000
Fax: (217) 244-1781
Lab: (217) 244-1606

Mailing Address:

Dept of Cell and Developmental Biology
University of Illinois B107
601 S. Goodwin Avenue
Urbana, IL 61801

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